|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
CTD_human |
The MTHFR CT polymorphism confers a high risk for stroke in both homozygous and heterozygous T allele carriers with Type 2 diabetes.
|
16681562 |
2006 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
CTD_human |
Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.
|
15534175 |
2004 |
|
Cerebrovascular accident
|
0.500 |
Biomarker
|
group |
CTD_human |
Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism.
|
19646848 |
2009 |
|
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Our findings indicate that the MTHFR 677C>T polymorphism may be associated with an elevated risk for CVD in ESRD patients, especially among Asians.
|
25050994 |
2014 |
|
Cardiovascular Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
The methylenetetrahydrofolate reductase C677T gene mutation is associated with hyperhomocysteinemia, cardiovascular disease and plasma B-type natriuretic peptide levels in Korea.
|
16958597 |
2006 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
A haplotype of the methylenetetrahydrofolate reductase gene predicts poor tumor response in rectal cancer patients receiving preoperative chemoradiation.
|
17047490 |
2006 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
|
18676755 |
2008 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Dietary factors and biomarkers involved in the methylenetetrahydrofolate reductase genotype-colorectal adenoma pathway.
|
17087956 |
2006 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.
|
15608557 |
2004 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer.
|
17245555 |
2007 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer.
|
16512993 |
2006 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Folate metabolism polymorphisms influence risk of colorectal adenoma recurrence.
|
16985020 |
2006 |
|
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer.
|
17350979 |
2007 |
|
Congenital Heart Defects
|
0.400 |
Biomarker
|
group |
CTD_human |
Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation.
|
16524890 |
2006 |
|
Kidney Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.
|
18551038 |
2008 |
|
Neural Tube Defects
|
0.400 |
Biomarker
|
group |
CTD_human |
A significant association between the MTHFR C677T polymorphism and NTD susceptibility was revealed in our meta-analysis ( TT versus CC: OR= 2.022, 95% CI: 1.508, 2.712; CT+TT versus CC: OR = 1.303, 95% CI: 1.089, 1.558; TT versus CC+CT: OR= 1.716, 95% CI: 1.448, 2.033; 2TT+CT versus 2CC+CT: OR= 1.330, 95% CI: 1.160, 1.525).
|
23056169 |
2012 |
|
Stomach Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.
|
18505952 |
2008 |
|
Stomach Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
DNA repair gene and MTHFR gene polymorphisms as prognostic markers in locally advanced adenocarcinoma of the esophagus or stomach treated with cisplatin and 5-fluorouracil-based neoadjuvant chemotherapy.
|
21347786 |
2011 |
|
Vascular Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
MTHFR 677C/T polymorphism is associated with the risk of vascular diseases due to hyperhomocysteinemia.
|
19646848 |
2009 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Breast cancer risk associated with multigenotypic polymorphisms in folate-metabolizing genes: a nested case-control study in Taiwan.
|
17595805 |
2007 |
|
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan.
|
16777985 |
2006 |
|
Lymphoma
|
0.390 |
Biomarker
|
group |
CTD_human |
Genetic polymorphism of folate and methionine metabolizing enzymes and their susceptibility to malignant lymphoma.
|
16799656 |
2005 |
|
Colonic Neoplasms
|
0.370 |
Biomarker
|
group |
CTD_human |
Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.
|
16284371 |
2005 |
|
Prostatic Neoplasms
|
0.340 |
Biomarker
|
group |
CTD_human |
Association between polymorphisms of folate-metabolizing enzymes and risk of prostate cancer.
|
17967524 |
2008 |
|
Lung Neoplasms
|
0.330 |
Biomarker
|
group |
CTD_human |
Folate-related genes and the risk of tobacco-related cancers in Central Europe.
|
17389614 |
2007 |